Will it work if the toothpaste has fluoride in it? Will it work on the weekend too?

...and your concern is? The mechanism is only in contact with the outside of the tube. It is agnostic to the contents in the tube being squeezed. As to the temporal state of the device. It is only present in one instance of the multiverse at a time, weekdays, and weekends, included.

Will the squeezer stand up straight with a full tube of toothpaste? Or do you have to wait for the tube to be partially empty before it stands up?

I used it on a brand new tube and it will stand up straight but only if you make sure you start the tube at as close to a 90 degree angle (straight up).

Manufacturer	AtFung
Package Dimensions	10.1 x 9.7 x 4.8 cm
Material	金属
Color	三角形ブラック
Special Features	丈夫で頑丈。
Package Weight	0.12 Kilograms
Batteries Required	No
Batteries Included	No
Brand Name	XYKEEY
Item Weight	0.2 Pounds

XYKEEY 歯磨き粉チューブ絞り器 - 2個セット 歯磨き粉絞りローラー メタル歯磨きチューブ絞り器シートホルダースタンド (トライアングルブラック)

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XYKEEY 歯磨き粉チューブ絞り器 - 2個セット歯磨き粉絞りローラーメタル歯磨きチューブ絞り器シートホルダースタンド (トライアングルブラック)