• Cellular Energy Production, Glucose and Lipid sm and Antioxidant Support Supplement: Contains one 60 count bottle of Jarrow Formulas R-Alpha Lipoic veggie s for a 60-day supply..
• Dietary supplement with 100 mg of R-Alpha Lipoic (RALA), a naturally occurring form of Alpha Lipoic to support cellular energy production, support glucose and lipid sm, and as an antioxidant helps to minimize oxidative stress..
• Each serving includes 150 mcg of Biotin to prevent Biotin deficiency associated with long-term Alpha Lipoic use..
• Suggested Use: Adults, take one once a day or as directed by your qualified care professional..
• These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease..

Product Description ------------------- Jarrow Formulas R-Alpha Lipoic provides an antioxidant that helps to minimize oxidative stress, daily cellular energy production, and glucose and lipid sm with one easy-to-take .* Made with high-quality, non-GMO ingredients, this vegan and gluten free dietary supplement contains no wheat, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts, or sesame. Each serving of this shelf-stable Jarrow Formulas supplement delivers 100 mg of R-Alpha Lipoic (RALA), a naturally occurring form of Alpha Lipoic found in s, animals, and the human body.* As an antioxidant with high bioavailability, these supplement s help support cellular energy production, glucose and lipid sm.* This RALA supplement also includes 150 mcg of Biotin to prevent Biotin deficiency associated with long-term Alpha Lipoic use.* Suggested Use: Adults, take one once a day or as directed by your qualified care professional. Informed by strong scientific research, Jarrow Formulas products are carefully crafted to ensure you get the benefit of each and every , mineral and supplement. .com ---- Jarrow Formulas R-Alpha Lipoic , 60 Vegetarian s ----------------------------------------------------------- At a Glance: ------------ * Supports energy production and y sm* * Helps regulate glucose and lipid sm* * Promotes the synthesis of glutathione and the induction of Phase II detoxification enzymes* * Includes D-biotin, a natural cofactor that may compliment RALA in promoting mitochondrial * * Ideal for those interested in enhancing energy production, sugar and lipid sm, and antioxidant protection* Supports energy production and y sm*. Includes D-biotin, a natural cofactor that may compliment RALA in promoting mitochondrial *. View larger ( https://images-na.ssl-images-.com/images/G/01/hpc/detail-page/c26-B005C99OWO-2-l.png ) . R-Alpha Lipoic : Natural Form of Alpha Lipoic ------------------------------------------------------ Most alpha lipoic (ALA) products contain a racemic mixture of R-Alpha Lipoic (R-ALA) and S-Alpha Lipoic (S-ALA). Generally, equal as of R- and S- forms are produced during the manufacturing process of alpha lipoic , and thus, these products contain R-ALA and S-ALA in an equal ratio of 1:1. However, R-ALA is the only form of lipoic that is endogenously synthesized in humans and other organisms. Human cokinetic studies have shown that peak concentrations of R-ALA are 40-50 percent higher than S-ALA after oral supplementation of racemic preparations, suggesting that R-ALA may have better absorption and bioavailability. In animal studies, R-ALA supplementation has shown better biological effects such as insulin-stimulated glucose transport, glucose sm, and antioxidative status. Thus, R-ALA may provide superior benefits compared to racemic mixtures (R-ALA and S-ALA) or S-ALA alone.* Energy Production and Glucose and Lipid sm -------------------------------------------------- One of the major functions of R-ALA is to enhance energy production via improved mitochondrial functions.* R-ALA is a disulfide compound and it is naturally found in mitochondria as a coenzyme for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, directly helping mitochondrial energy production. It also helps mitochondria as an efficient antioxidant by protecting against oxidative stress that may impair or slow down mitochondria.* Further, R-ALA is known to stimulate y glucose sm.* In clinical studies, supplementation supported blood glucose levels, insulin activity and insulin sensitivity without reported side effects. This efficient glucose sm seems to contribute to y lipid sm as well.* Powerful Antioxidant -------------------- R-ALA works in many ways to enhance cellular antioxidant status.* For example, supplementation of lipoic significantly increases biosynthesis of glutathione, a potent antioxidant that protects cells from reactive oxygen species. In vitro studies have shown that lipoic stimulates the expression of gamma-glutamylcysteine lie, the rate limiting enzyme in the glutathione synthesis pathway, as well as cellular uptake of cysteine, an amino required for glutathione synthesis, resulting in an overall increase in intracellular glutathione by 30-70 percent.* Some of the R-ALA absorbed from the diet or synthesized in the body can be converted into DHLA (dihydrolipoic ), the active-antioxidant form of R-ALA. Studies have shown that DHLA plays a key role in recycling many antioxidants including s and other molecules involved in various redox systems. For example, it has been reported that DHLA is superior in its ability to regenerate C from its oxidized form compared to glutathione. DHLA can also reactivate alpha-tocopherols directly or do so indirectly by converting C to its reduced form, which then reduces oxidized alpha-tocopherol. Similarly, DHLA reactivates oxidized glutathione and prevents lipid peroxidation. These recycled antioxidants, such as C and glutathione, can further recycle other antioxidants such as E, keeping the "antioxidant network" operating smoothly. Lastly, DHLA interacts with NADPH- or NADH-dependent electron transport systems to recycle E.* Inducer of Phase II Detoxification Enzymes ------------------------------------------ R-ALA also stimulates the expression of various phase II detoxification enzyme genes. For example, cells that were treated with lipoic showed a dose- and time-dependent increase in gene expression of GSTA2, glutathione S-transferase A2, a phase II detoxification enzyme that plays a role in the elimination of carcinogens, drugs, environmental toxins and products of oxidative stress.* Activation of phosphatidylinositol 3-kinase (PI3K)-dependent CCAAT/enhancer binding protein (C/EBP) has been suggested as one of the possible mechanisms of induced phase II detoxification enzyme expression. Similarly, multiple studies have shown that supplementation of lipoic induces neuroprotective phase II detoxification enzymes, NAD(P)H:quinone oxidoreductase (NQO1) and glutathione-S-transferase (GST) in cultured neuronal cells (e.g. human neuroblastoma SH-SY5Y, and C6 astroglial cells) in a dose- and time-dependent manner. also increased endogenous antioxidants, providing additional neuroprotective effects.* Therefore, R-ALA supplementation may protect cells from various types of damage by efficiently eliminating toxins and unwanted materials.* Biotin Supplementation and Its Significance ------------------------------------------- Biotin (B7) is a water-soluble B that serves as a cofactor for many enzymes including pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase. These enzymes play critical roles in mammalian gluconeogenesis, ty synthesis, propionate sm, and the catabolism of leucine. Thus, biotin supplementation, along with R-ALA, will further support y sm and energy production.* Note: ----- If you have a medical condition (especially es or being treated for glucose control), are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (especially for glucose control), consult your care practitioner before using this product. About Jarrow Formulas --------------------- Jarrow Formulas' complete line of over 350 tional products includes s, minerals, probiotics, standardized al concentrates, amino s, enzymes and enteral tion products. Customers can be assured of purity, value and potency when choosing these products. What's in the Box ----------------- Jarrow Formulas R-Alpha Lipoic , 60 Vegetarian s. Other Products from Jarrow Formulas: ------------------------------------