115 zł

Description

About this item Bioclinic Naturals 5-MTHF & B12 contains biologically active folic in the form 5-Methyltetrahydrofolic Each lozenge also provides 50 mcg methylcobalamin, the primary circulating and biologically active form of B12 In a base of active extracts, including many vegetables, and other bioactive compounds, including Theracurmin curcumin Lozenges are suitable for vegetarians, and allow for easy dosing.

Bioclinic Naturals 5-MTHF & B12 provides the most biologically active forms of two complementary B s. (6S)-5-Methyltetrahydrofolate or MTHF is the active form of folate at the cellular level, the form found in circulation and the only to cross the blood brain barrier. It does not need to be converted to an active form by the enzyme methylene tetrahydrofolate reductase or MTHFR, known to have common single-nucleotide polymorphisms that impair enzymatic activity by as much as 70 percent. Furthermore, quatrefolic administration has been associated with higher peak 5-MTHF levels than both folic and calcium 5-MTHF, with higher plasma folate levels even in those with high functioning MTHFR polymorphisms. While (6S)-5-Methyltetrahydrofolate does not a B12 deficiency as folic supplementation alone may, these two s have complementary roles in methylation pathways that warrant combined use. Methylcobalamin is the principle circulating form of B12, and is a direct cofactor for B12-dependent enzymes. It has direct biological activity, in contrast to cyanocobalamin, which is synthetically derived. When combined with other B s, B12 has been shown to be more effective.

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Bioclinic Naturals 5-MTHF & B12 Biologically Active Folic - 60 Lozenges

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